Skip to main content

Borago officinalis L. (Boraginaceae)

(Syn.: B. hortensis L.)

  • Chapter
  • First Online:
Handbook of 200 Medicinal Plants

Abstract

An annual herbaceous and hairy herb, native to the Mediterranean region, but naturalized in other parts of the world, North Africa and Asia Minor; cultivated as an ornamental and medicinal plant, and very widely introduced in most of Europe. In Iranian traditional medicine, the flowers are known to possess sedative property, the leaves are used for their anticonvulsant, bronchodilator, vasodilator, and cardiodepressant properties, and borage seed oil is used for treatment of diseases such as, multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In many parts of Italy, wild plants are consumed as vegetables, and borage is one of the most commonly used plants in both southern and northern Italy, and also used in local traditional medicine to treat inflammatory diseases. In Mexico, it is also regarded to have nutritional value, and is used to treat gastrointestinal diseases, and respiratory diseases. It is used in Danish folk medicine to treat depression and anxiety, and borage oil is promoted in the United States as a treatment for rheumatoid arthritis, atopic dermatitis, diabetic neuropathy, and menopause-related symptoms. Leaves contain small amount of pyrrolizidine alkaloids, rosmarinic acid, officinalioside, actinidioionoside, roseoside, crotalionoside C and kaempferol 3-O-β-d-galactopyranoside, essential oil, fatty acids, and a significant amount of manganese. Mice fed with borage diet ad lib for 12-months showed reversal of age-related inflammatory and senile osteoporosis. Ethanol extract of aerial parts possesses MAO-A inhibitory activity, showed affinity to serotonin transporter, and potential as a serotonin reuptake inhibitor. Daily administration of hydroethanol extract to patients with moderate asthma, significantly ameliorated cough, dyspnea, wheezing, nocturnal symptoms, and airway hyperresponsiveness, and significantly reduced exacerbation attacks per month.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Al-Khamees WA, Schwartz MD, Alrashdi S, Algren AD, Morgan BW. Status epilepticus associated with borage oil ingestion. J Med Toxicol. 2011;7:154–7.

    Article  Google Scholar 

  2. Andrade-Cetto A. Ethnobotanical study of the medicinal plants from Tlanchinol, Hidalgo. México. J Ethnopharmacol. 2009;25:163–71.

    Article  Google Scholar 

  3. Asadi-Samani M, Bahmani M, Rafieian-Kopaei M. The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review. Asian Pac J Trop Med. 2014;7S1:S22–8.

    Google Scholar 

  4. Bandoniene D, Murkovic M, Venskutonis PR. Determination of rosmarinic acid in sage and borage leaves by high-performance liquid chromatography with different detection methods. J Chromatogr Sci. 2005;43:372–6.

    Article  CAS  Google Scholar 

  5. Bandoniene D, Murkovic M. The detection of radical scavenging compounds in crude extract of borage (Borago officinalis L.) by using an on-line HPLC-DPPH method. J Biochem Biophys Methods. 2002;53:45–9.

    Google Scholar 

  6. Baharvand-Ahmadi B, Bahmani M, Tajeddini P, Rafieian-Kopaei M, Naghdi N. An ethnobotanical study of medicinal plants administered for the treatment of hypertension. J Renal Inj Prev. 2016;5:123–8.

    Article  Google Scholar 

  7. Conforti F, Sosa S, Marrelli M, et al. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. J Ethnopharmacol. 2008;116:144–51.

    Article  CAS  Google Scholar 

  8. Foster RH, Hardy G, Alany RG. Borage oil in the treatment of atopic dermatitis. Nutrition. 2010;26:708–18.

    Article  CAS  Google Scholar 

  9. Ghirardini MP, Carli M, del Vecchio N, et al. The importance of a taste. A comparative study on wild food plant consumption in twenty-one local communities in Italy. J Ethnobiol Ethnomed. 2007;3:22.

    Google Scholar 

  10. Herrmann M, Joppe H, Schmaus G. Thesinine-4′-O-beta-d-glucoside the first glycosylated plant pyrrolizidine alkaloid from Borago officinalis. Phytochemistry. 2002;60:399–402.

    Article  CAS  Google Scholar 

  11. Jäger AK, Gauguin B, Andersen J, Adsersen A, Gudiksen L. Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A. J Ethnopharmacol. 2013;145:822–5.

    Article  Google Scholar 

  12. Jaradat NA, Damiri B, Abualhasan MN. Antioxidant evaluation for Urtica urens, Rumex cyprius and Borago officinalis edible wild plants in Palestine. Pak J Pharm Sci. 2016;29(1 Suppl):325–30.

    CAS  PubMed  Google Scholar 

  13. Kast RE. Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. Int Immunopharmacol. 2001;1:2197–9.

    Article  CAS  Google Scholar 

  14. Kim J, Kim H, Jeong do H, et al. Comparative effect of gromwell (Lithospermum erythrorhizon) extract and borage oil on reversing epidermal hyperproliferation in guinea pigs. Biosci Biotechnol Biochem. 2006;70:2086–95.

    Google Scholar 

  15. Leos-Rivas C, Verde-Star MJ, Torres LO, et al. In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica. J Med Food. 2011;14:866–9.

    Article  Google Scholar 

  16. Lüthy J, Brauchli J, Zweifel U, Schmid P, Schlatter C. Pyrrolizidine alkaloids in medicinal plants of Boraginaceal: Borago officinalis L. and Pulmonaria officinalis L. Pharm Acta Helv. 1984;59:242–6 (German).

    Google Scholar 

  17. Maffè S, Cucchi L, Zenone F, et al. Digitalis must be banished from the table: a rare case of acute accidental digitalis intoxication of a whole family. J Cardiovasc Med (Hagerstown). 2009;10:727–32.

    Article  Google Scholar 

  18. Marrelli M, Loizzo MR, Nicoletti M, Menichini F, Conforti F. In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as antiobesity agents with α-amylase and pancreatic lipase inhibitory activities. J Sci Food Agric. 2014;94:2217–24.

    Article  CAS  Google Scholar 

  19. Mhamdi B, Aidi Wannes W, Marzouk B. Biochemical evaluation of borage (Borago officinalis) rosette leaves through their essential oil and fatty acid composition. Ital J Biochem. 2007;56:176–9.

    CAS  PubMed  Google Scholar 

  20. Mirsadraee M, Khashkhashi Moghaddam S, Saeedi P, Ghaffari S. Effect of Borago officinalis extract on moderate persistent asthma: a phase two randomized, double blind, placebo-controlled clinical trial. Tanaffos. 2016;15:168–74.

    PubMed  PubMed Central  Google Scholar 

  21. Morteza E, Akbari GA, Moaveni P, et al. Compositions of the seed oil of the Borago officinalis from Iran. Nat Prod Res. 2015;29:663–6.

    Article  CAS  Google Scholar 

  22. Piccillo GA, Miele L, Mondati E, et al. Anticholinergic syndrome due to ‘Devil’s herb’: when risks come from the ancient time. Int J Clin Pract. 2006;60:492–4.

    Article  CAS  Google Scholar 

  23. Renna M, Cocozza C, Gonnella M, Abdelrahman H, Santamaria P. Elemental characterization of wild edible plants from countryside and urban areas. Food Chem. 2015;177:29–36.

    Article  CAS  Google Scholar 

  24. Rivera D, Obón C. The ethnopharmacology of Madeira and Porto Santo Islands, a review. J Ethnopharmacol. 1995;46:73–93.

    Article  CAS  Google Scholar 

  25. Samy MN, Hamed AN, Sugimoto S, et al. Officinalioside, a new lignan glucoside from Borago officinalis L. Nat Prod Res. 2016;30:967–72.

    Article  CAS  Google Scholar 

  26. Shahraki MR, Ahmadimoghadm M, Shahraki AR. The antinociceptive effects of hydroalcoholic extract of Borago Officinalis flower in male rats using formalin test. Basic Clin Neurosci. 2015;6:285–90.

    PubMed  PubMed Central  Google Scholar 

  27. Vacillotto G, Favretto D, Seraglia R, et al. A rapid and highly specific method to evaluate the presence of pyrrolizidine alkaloids in Borago officinalis seed oil. J Mass Spectrom. 2013;48:1078–82.

    Article  CAS  Google Scholar 

  28. Wauquier F, Barquissau V, Léotoing L, et al. Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis. Bone. 2012;50:553–61.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahid Akbar .

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Akbar, S. (2020). Borago officinalis L. (Boraginaceae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_46

Download citation

Publish with us

Policies and ethics