Cavani gave his country the lead from the penalty spot in their opening match with Costa Rica on Saturday, but the Central American nation responded sensationally to claim a shock 3-1 win.
There is now little margin for error against Group D heavyweights England and Italy, starting with the much-anticipated showdown with Roy Hodgson's team in Sao Paulo on Thursday.
But it is a scenario Uruguay are more than familiar with, having come through intercontinental play-offs to reach their past three World Cups.
The bulk of the squad that reached the semi-finals in South Africa four years ago and went on to claim 2011 Copa America glory remain together, and Forlan believes this could also be a factor in Uruguay's favour.
The 35-year-old told FIFA.com: "Of course it won't be easy but this team has been together for a long time and we know what we're capable of.
"We have to do our work on the pitch, play as we know how, and I believe that will be sufficient to achieve the results we need."
Asked whether his national team produce their best under pressure, Cavani added: "It's true, people say that a lot about Uruguay. We have gone through a lot and have always survived.
"Play-offs, difficult matches, extreme situations – and here we are. This generation has won almost everything and knows how to do so."